Class: Nasal Antihistamine
Dosage Forms. Nasal Spray: 137 mcg/actuation
Common FDA Label Indication, Dosing, and Titration.
1. Perennial allergic rhinitis: 2 sprays per nostril bid
2. Seasonal allergic rhinitis: 1-2 sprays per nostril bid
3. Vasomotor rhinitis: 2 sprays per nostril bid
Off-Label Uses. None
MOA. Azelastine is a selective H1-receptor antagonist that blocks release of histamine from cells involved in the allergic response. It also inhibits other mediators of allergic reactions (eg, leukotrienes, etc), and reduces chemotaxis and eosinophil activation.
Drug Characteristics: Azelastine
Medication Safety Issues: Azelastine
Drug Interactions: Azelastine
Adverse Reactions: Azelastine
Efficacy Monitoring Parameters. Decrease in rhinitis symptoms.
Toxicity Monitoring Parameters. Seek medical attention if severe allergic reactions occur.
Key Patient Counseling Points. Avoid spraying in eyes. Somnolence has been reported with nasal administration; instruct patient to avoid alcohol use and hazardous activities such as driving or operating machinery until level of sedation is known.
Clinical Pearls. Also available as ophthalmic drop for ocular rhinitis symptoms.