Operative Techniques in Orthopaedic Surgery (4 Volume Set) 1st Edition

402. Elbow Replacement for Acute Trauma

Srinath Kamineni

DEFINITION

images Most comminuted elbow fractures have significant associated soft tissue injuries, which are often of equal or greater importance to the bony element.

images The key point in determining how to treat acute elbow fractures is to assume that all fractures will be anatomically reduced and fixed.

images An acute elbow replacement should be considered only if it is felt that open reduction and internal fixation is unlikely to achieve a predictably good functional outcome.

images In the vast majority of cases, elbow replacements for the treatment of acute fractures should be limited to the physiologically elderly patient with low demands and osteoporotic bone stock.

ANATOMY

images The bony anatomy of the elbow consists of the distal humerus, proximal ulna, and proximal radius.

images Important soft tissue stabilizers include the medial and lateral ligamentous complexes and surrounding musculature, especially the brachialis, common flexor and common extensor masses, and triceps.

images The ulnar nerve is tethered to the medial condylar– epicondylar fragment by the cubital tunnel retinaculum distally and the arcade of Struthers proximally.

PATHOGENESIS

images Elbow injuries are often the result of direct impact—for example, a direct blow on the elbow during a fall.

images Knowing the energy of the fracture is important to gauge the likelihood of associated injuries.

images Less energy is required to create a comminuted fracture in elderly and osteoporotic individuals, but muscular injuries of the triceps and brachialis are common, with a subsequent influence on the functional outcome.

images The ulnar nerve displaces with the medial fragment. As a consequence, the nerve may kink, leading to a local nerve injury. Nerve lacerations are an uncommon consequence of comminuted distal humeral fractures.

NATURAL HISTORY

images Most distal humeral fractures are treatable with either open reduction and internal fixation (ORIF) or nonoperative management. The challenging fracture subgroups are those that involve the articular surfaces and are comminuted.

images Many direct and indirect soft tissue complications may ensue, including neurovascular entrapment,2,6 muscle tears leading to myositis ossificans,6,11,15 and soft tissue contracture with joint stiffness.

images There is some evidence to suggest that congruently reducing and fixing a comminuted intra-articular distal humeral fracture does not eliminate the risk of posttraumatic arthritis,7 although, where possible, ORIF should remain the primary goal.

PATIENT HISTORY AND PHYSICAL FINDINGS

images The physical examination (FIG 1) should be performed gently in the presence of fractures, especially when comminution suggests the possibility of neurovascular injury if the examination is too vigorous.

images A complete examination of the elbow should also include evaluation of associated injuries. It should begin away from the elbow, progressing toward it.

images The following associated injuries should be ruled out.

images Distal radial and scaphoid fractures: Since the most common mechanism of injury is a fall onto an outstretched hand, the energy transfer of the fall begins in the extended wrist, through the distal radius and scaphoid. Direct palpation of the distal radius should be done and anatomic snuffbox tenderness should be elicited. Palpation of the scaphoid tubercle and ulnar and radial deviation of the wrist may also identify a scaphoid injury.

images Distal radioulnar joint disruption: Ballottement of the ulnar head should be done in the volar and dorsal directions, in pronation and supination. A disrupted joint is often painful with such ballottement, and the ulnar head may be prominent with the forearm in pronation.

images Fracture extension beyond the elbow: The examiner should palpate the ulna shaft, along its subcutaneous border, from the wrist to the olecranon.

images Interosseous membrane injury: Palpating the interval between the bones of the forearm is not a sensitive examination but can raise suspicion for an Essex-Lopresti injury,

images

FIG 1 • Typical appearance of an elbow with an underlying fracture with extensive swelling and bruising.

images

FIG 2 • Standard AP and lateral plain radiographs.

leading to further imaging. If an interosseous membrane disruption is present, this will influence the type of implant used for elbow replacement (one with a radial head replacement), but the pathology is not commonly described.

IMAGING AND DIAGNOSTIC STUDIES

images Plain radiographs, including anteroposterior (AP) and lateral views (FIG 2) of the elbow and both wrists, should be obtained. The elbow view may have to be taken in a protective splint or plaster back-slab for patient comfort.

images Elbow radiographs will allow initial assessment of the degree of comminution and may indicate the presence of decreased bone mineral density.

images Bilateral wrist views will indicate the presence of an axial (interosseous membrane) injury if the ulnar head is in positive variance compared to the contralateral uninjured wrist.

images Plain tomograms are of use in improving the understanding of the fracture configuration, but an alternative would be a computed tomography (CT) scan. With the latter the surgeon can view a three-dimensional reconstruction, which is a useful surgical planning tool.

images If there is evidence on physical examination of a neurologic injury, it is prudent to document its extent with a carefully performed neurologic examination.

DIFFERENTIAL DIAGNOSIS

images Nonunion

images Ligamentous disruption

images Fracture-dislocation

NONOPERATIVE MANAGEMENT

images The “bag-of-bones” technique is a nonoperative method of treatment described by Eastwood that encourages the compressive molding of the comminuted distal humeral fracture fragments.

images Subsequent rehabilitation with collar and cuff support achieves substandard but acceptable results only in the elderly and debilitated group of patients who have almost no demand on elbow function.

images This type of treatment does not achieve acceptable results with respect to stability and strength in younger patients.

SURGICAL MANAGEMENT

Open Reduction and Internal Fixation

images ORIF has been widely documented for comminuted fractures of the distal humerus.

images Some reported series demonstrate good results with fixation of such challenging fractures, with better results predominantly in the younger age groups.12,16 Rarely are good results achieved in the elderly, osteoporotic group.7

images Many series report less-than-satisfactory outcomes in the elderly treated by operative fixation.12

images A direct comparison of internal fixation to primary total elbow replacement in the elderly osteoporotic group revealed that replacement produced no poor results and no need for revision surgery at 2 years of follow-up. The internal fixation group produced three poor results requiring revision to a total elbow replacement.4

Elbow Arthroplasty

images When a distal humerus fracture is not reconstructable, arthroplasty becomes a valid treatment option.

images Elbow replacement following a failed attempt at fixation has proven to have a significantly worse outcome than if the arthroplasty was performed initially.3

images There are a number of studies that support the concept of an acute total elbow arthroplasty in select patients with comminuted fractures of the distal humerus.1,3,9

images The more traditional form of replacement for the elderly and low-demand population with an unreconstructable distal humerus fracture is the total elbow arthroplasty.

images A more recent innovation has been the replacement of the distal humerus (hemiarthroplasty) to preserve an intact ulna and radial head.13 This procedure is not FDA approved and so should be considered experimental and not for general consideration, especially since the elbow joint is variable and highly congruent in its topography, which differs from many of the standard implants used for acute fractures.

Indications and Contraindications

images Indications for acute total elbow arthroplast.

images Comminuted, unreconstructable distal humerus fracture

images Physiologically elderly patient

images Low-demand patient

images Indications for acute elbow hemiarthroplast.

images Unreconstructable distal humeral fracture (C3)

images Unreconstructable combined fractures of capitellum and trochlea

images Very low bicondylar T fracture of distal humeru.

images Young patient

images Active patient

images Repairable or intact collateral ligaments (may require reconstruction of the medial and lateral supracondylar columns)

images Repairable or intact radial head

images Absolute contraindications for acute joint replacemen.

images Infection (overt)

images Lack of soft tissue coverage (skin, muscle)

images Relative contraindications for acute joint replacemen.

images Infection in distant body part

images Contaminated wound

images Neurologic injury involving the elbow flexors

Preoperative Planning

images Standard radiographs should be obtained (AP and lateral).

images If doubt exists regarding the ability to anatomically repair the fracture, then a CT scan should be requested to assess the degree of comminution and the fracture line orientation.

images An assessment of humeral shaft bone loss is important in planning the implant design that might be considered. If the degree of loss is greater than the articular condylar fragments, an implant that has the ability to restore humeral length will be more appropriate. If an unreconstructable fracture of the humeral articular surfaces without humeral shaft bone loss is encountered, an implant with the ability to resurface the articular surfaces as a hemiarthroplasty or a resurfacing ulnotrochlear replacement can be considered, but the former implantation technique should be regarded as an off-label and experimental procedure.

images Humeral shaft length loss of 2 cm can be tolerated and standard implants used.

images Humeral shaft length loss of greater than 2 cm can be restored with implant designs with anterior flanges, especially those with extended flanges that allow restoration of humeral length.

images The surgeon should assess the intramedullary canal dimensions of the humerus and ulna. This will help to plan the requirement of extra-small diameter.

images Neurovascular status of the limb should be fully assessed and documented in the clinical notes.

Patient Positioning

images Two methods of patient positioning can be used, depending on surgeon comfort and the access required:

images Supine: The arm is draped for maximum maneuverability. During the procedure the arm is supported on a large rolled towel placed on the patient's upper thorax, carefully avoiding the endotracheal tube, stabilized by an assistant. In this position the surgeon stands on the side of the patient's injured limb (FIG 3A).

images Lateral decubitus: The arm is positioned on an arm support, thereby minimizing the need for an assistant, but this set-up is less maneuverable. In this position the surgeon stands on the opposite side of the patient's injured limb (FIG 3B).

Surgical Approach

images Two main surgical approaches are useful for acute total elbow arthroplasty:

images Triceps-splitting approach

images Bryan-Morrey approach

images The triceps should be carefully managed in either approach, and it often has a thin tendon, especially in older patients and those with rheumatoid arthritis. The triceps tendon should be dissected from the olecranon with a small curved scalpel blade, maintained perpendicular to the interface between the tendon and bone.

images

FIG 3A. Patient positioned in a supine position. The elbow is isolated and placed on a roll of towel placed on the patient's chest, and stabilized by an assistant. The surgeon must take care to avoid the neck and anesthetic equipment. B. Patient positioned in a lateral decubitus position with the elbow draped over an arm support.

TECHNIQUES

INCISION AND DISSECTION

images Make a midline longitudinal skin incision (TECH FIG 1A), with a gentle curve to avoid the olecranon weight-bearing prominence. Extend the incision 5 cm distal to and proximal to the prominence of the olecranon tip.

images Develop the full-thickness medial and lateral skin flaps (TECH FIG 1B) and define the medial and lateral borders of the triceps (TECH FIG 1C,D).

images At the medial border, define and partially neurolyse the ulnar nerve, and mark and handle it with a tied vessel loop (without an attached hemostat, since its constant weight may cause inadvertent nerve injury) (TECH FIG 1E).

images With the nerve visualized and handled to safety, remain in the medial gutter to extend the dissection distally to define the medial fracture fragment. Transect the medial collateral ligament in its entirety, and remove all soft tissue from this bony fragment and remove the latter (TECH FIG 1F).

images

TECH FIG 1A. Skin incision is posterior longitudinal, with or without a small diversion to avoid the “point” of the olecranon. B. Raising the skin should aim to maintain the full thickness of the flaps by using the “flat knife” technique. C. The medial and lateral borders of the triceps are defined (arrows). D. This patient had an anconeus epitrochlearis (star) in relation to the ulna nerve (UN). E. A vessel loop is used to maneuver the nerve without an attached clip. F. The medial fragment of the fracture is removed once all the soft tissues are released from it, and the nerve is gently retracted to ensure tension-free removal.

TRICEPS MANAGEMENT

Triceps Preserving

images With the ulnar nerve gently medially retracted, use a periosteal elevator to define the plane between the triceps and the posterior humerus, from the medial to the lateral border, exiting posterior to the lateral intermuscular septum. Use this elevator to lift the triceps, with blunt dissection, by sliding the shaft of the elevator proximal and distal in the interface (TECH FIG 2A).

images Develop the lateral triceps–lateral intermuscular septum margin and resect the lateral fracture fragments, having firstly cleared them of soft tissue attachments (TECH FIG 2B).

images While in the lateral corridor, visualize the radial head and resect sufficient head to prevent abutment on the prosthesis.

images From the lateral margin of the humeral shaft, raise the brachialis from 2 to 3 cm of the anterior surface.

Modified Bryan-Morrey Approach

images Preserving the integrity of the triceps insertion makes component insertion more difficult. An alternative approach for managing the triceps is to reflect it from the tip of the olecranon from medial to lateral, thereby improving exposure (TECH FIG 3).

images Define the medial triceps border and dissect the ulna nerve free from its connections, while protecting it in a vessel loop. The nerve is transposed into a subcutaneous pocket.

images The medial triceps is dissected to its ulna attachment. Release the triceps from the medial condylar fragments and transect the medial collateral ligament. Free the medial fragments from soft tissue attachments and remove the medial fragments between the triceps and a gently anteriorly retracted ulnar nerve.

images

TECH FIG 2A. A periosteal elevator is introduced between the triceps and the humeral shaft and the two structures are separated by sliding the elevator proximally and then distally to the level of the triceps insertion. B.The lateral corridor is defined and lateral fragments are removed.

images Develop the interval between the anconeus and flexor carpi ulnaris along the subcutaneous border of the ulna.

images The triceps tendon is sharply elevated from the olecranon, in continuity with the anconeus, and subluxed laterally. Take care to release the Sharpey fibers adjacent to the bone in order to retain the flap thickness. Further access is afforded by raising the anconeus from its ulnar attachment while maintaining its attachment distally.

images As the triceps is reflected laterally, the lateral condylar fragments are identified and removed by releasing the lateral collateral ligament and common extensor tendon.

images

TECH FIG 3A. The triceps is split through its central tendon, in line with the fibers. The tendinous portion is dissected from the olecranon to gain access to the ulna. B,C. To dissect the Sharpey fibers off the ulna, the surgeon uses the scalpel parallel to the ulna surface and maintains the release directly adjacent to the bone. D. Comminuted distal humeral fracture in an osteoporotic elderly woman, with CT imaging confirming significant articular comminution. This is the view through the triceps split.

BONE PREPARATION

images Identify the olecranon fossa (if any part of it still exists). This landmark is the seating point for the base of the anterior flange of the Coonrad-Morrey humeral component (TECH FIG 4A). If the olecranon fossa is not present owing to a greater degree of comminution, an extended-flange humeral component can be used.

images Release the anterior capsule and any soft tissue from the anterior surface of the distal humerus. This provides a site for the anterior humeral bone graft.

images The posterior flat surface of the humerus is identified since this plane approximates the axis of rotation of the distal humerus (TECH FIG 4B). Humeral canal preparation is completed with the canal broaches provided with the implant system being used.

images The ulnar canal preparation commences with removal of the tip of the olecranon. The intramedullary canal is entered at the base of the coronoid (TECH FIG 4C,D).

images The entry point is enlarged up toward the coronoid with a burr to allow easier component insertion without cortical abutment, which leads to malalignment (TECH FIG 4E).

images

images

TECH FIG 4A. The humeral component entry point, the apex of the olecranon fossa, is identified and humeral canal preparation is commenced by opening the canal with a bone nibbler or burr. B. The posterior flat surface of the humeral shaft is identified and the component is aligned. C,D. Ulnar canal preparation is commenced by opening the canal at the base of the coronoid process with a drill or burr. E.The trajectory of the ulnar component (black ring) is prepared by rasping the entry track posteriorly into the ulna with a rasp or bone nibbler (gray crescent). F,G. The tip of the coronoid should be resected sufficiently to prevent abutment on the humeral flange during full flexion. Also shown are the resections of the olecranon and the entry point for the ulnar stem insertion. H. The partially resected radial head is used as a bone graft for incorporation behind the humeral flange.

images During intramedullary preparation, the broaches must parallel the subcutaneous border of the ulna. This ensures that the track of insertion of the ulna parallels the intramedullary canal.

images The tip of the coronoid is removed to avoid impingement during terminal flexion (TECH FIG 4F,G).

images The radial head does not need to be resected if there is no disease of the proximal radioulnar joint (TECH FIG 4H).

IMPLANT INSERTION AND TENSIONING

images With the canal preparation completed (TECH FIG 5A), including pulse lavage of the medullary canals and cement restrictor placement, implant insertion can commence (TECH FIG 5B,C).

images Humeral insertion

images When bone loss is at or below the level of the olecranon fossa, standard humeral insertion can occur. If bone loss occurs above the olecranon fossa (greater than 2 cm), then humeral length must be restored.

images Prepare a wedge-shaped bone “cookie” for placement behind the humeral flange.

images Inject antibiotic cement into the humerus.

images When inserting the humeral component, place the bone graft behind the anterior flange. Because the humeral condyles have been resected, the implant can be completely seated and coupled once the cement has hardened.

images

TECH FIG 5A. The prepared bony surfaces, with the fracture fragments removed, and just before implantation. B. The linked Coonrad-Morrey replacement is cemented and linked in situ. C. If in terminal extension there is abutment of the tip of the olecranon on the implant, the surgeon resects the olecranon tip (OT) but should not approach the triceps insertion footprint.

images Maintain the component orientation relative to the posterior flat surface of the distal humerus.

images Seat the component and flange until the flange is completely engaged with the anterior cortex.

images Ulnar component insertio.

images Inject antibiotic cement into the ulnar canal.

images The ulnar component is inserted such that the axis of rotation is recreated and the implant is perpendicular to the dorsal flat surface of the olecranon.

TRICEPS REATTACHMENT

images The triceps is reattached using a nonabsorbable suture in a running locking mode (eg, running Krakow stitch) to achieve predictable purchase (TECH FIG 6A,B).

images Avoid capturing large amounts of triceps muscle fibers within the locking loops.

images The triceps tendon should be reattached to the flat of the olecranon process, not to the tip (TECH FIG 6C,D). Pass the sutures through bone tunnels (oblique crossing) that begin on the periphery of the flat reattachment area of the olecranon (TECH FIG 6E).

images Avoid tying the sutures directly over the midline of the proximal ulna, which is a source of painful symptoms and may require knot removal. Place the knot under the anconeus.

images When tensioning the triceps at reattachment, place the elbow at 30 to 45 degrees of flexion while tying the knot.

images Use a separate absorbable suture to “cinch” the triceps footprint onto the reattachment area (TECH FIG 6F).

images

images

TECH FIG 6A,B. A running locking stitch is used to improve triceps purchase when reattaching the muscle to the ulna. A. An example of a running locking stitch on either side of the split tendon. B. A locking stitch that locks both sides of the split together with one continuous locking suture. It is then reinforced with a reversed across-split locking suture. C,D. The triceps footprint to which reattachment should be attempted is predominantly on the flat part of the ulna or olecranon process, and not the tip, which is resected to prevent posterior abutment. E. Drill holes (1.5 to 2 mm) are oriented in a crossing fashion to secure the triceps to the footprint area. F. A separate “cinch” suture is used to increase the security and the area of contact between the triceps and the ulna, thereby improving healing potential.

WOUND CLOSURE

images The ulnar nerve is transposed into an anterior subcutaneous location.

images Reapproximate the triceps to the flexor and extensor masses with absorbable suture. Do not overtighten this repair, as it will restrict motion.

images The use of a subcutaneous drain is a matter of surgeon preference. However, there is no literature demonstrating the efficacy of a postoperative drain in preventing hematoma.

PEARLS AND PITFALLS

images

POSTOPERATIVE CARE

images A volar plaster or thermoplastic splint is used to maintain the elbow in full extension for the first several days. This avoids tension on the incision and on the triceps reattachment.

images The arm is elevated on pillows or with a Bradford sling overnight to prevent edema.

images Nonsteroidal anti-inflammatories are avoided because of their detrimental effects on tissue healing (bone to tendon and bone to bone).

images On the second day after surgery the dressing is removed and the compliant patient should commence gentle active antigravity flexion, with passive gravity-assisted extension.

images Graduated and targeted motion is prescribed, with greater than 90 degrees of elbow flexion attempted after 5 weeks. This allows sufficient time for the triceps to adhere and heal (incompletely) to the ulna. Aggressive flexion too early may result in triceps avulsion or pull-out. Triceps antigravity exercises can commence after 5 weeks.

images Always, at each patient interaction, the surgeon should reiterate the restrictions of use with an elbow arthroplasty: limited internal (varus) and external (valgus) rotatory torques, 2-pound repetitive and 10-pound single-event lifting.

COMPLICATIONS

images Triceps avulsion

images Stiffnes.

images Overlengthened implantation

images Overtensioned triceps reattachment

images Overzealous closure of triceps to flexor–extensor compartments

images Inadequate soft tissue release

images Impingemen.

images Radial head on humeral component (distal yolk)

images Coronoid on humeral component (anterior yolk)

images Olecranon process on posterior humerus

images Deep venous thrombosis

images Infection

images Periprosthetic fractur.

images Osteoporotic bone

images Stem–canal mismatched sizes

images Stem–canal mismatched curvature

images Inadequate opening for ulna component at coronoid base

images Ulna nerve neuropathy or injury

OUTCOMES

images Cobb and Morrey1 reported 15 excellent and 5 good results, with one patient with inadequate data, in a cohort of patients with acute distal humeral fractures (average age 72 years) at 3.3 years of follow-up.

images Ray et al14 reported 5 excellent and 2 good functional results in a group of patients with an average age of 81 years at 2 to 4 years of follow-up.

images Gambirasio et al5 reported excellent functional results in a cohort of 10 elderly patients with osteoporotic intra-articular fractures.

images Frankle et al4 compared the outcomes of patients over age 65 with comminuted intra-articular distal humeral fractures treated with ORIF versus acute total elbow replacements. The ORIF group had 8 excellent results, 12 good results, 1 fair result, and 3 poor results, with 3 patients requiring conversion to elbow replacement. All 12 acute primary elbow replacements achieved excellent (n = 11) or good (n = 1) results.

images Kamineni and Morrey8 reported an average Mayo Elbow Performance Score (MEPS) of 93/100 in a series of 49 acute distal humeral fractures (average patient age 67 years) at 7 years of follow-up. The average arc of motion was 107 degrees.

images Lee et al10 reported seven acute elbow replacements for distal humeral fractures in patients with an average age of 73 years. The average arc of motion was 89 degrees and the average MEPS was 94/100 at an average follow-up of 25 months.

REFERENCES

· Cobb TK, Morrey BF. Total elbow arthroplasty as primary treatment for distal humeral fractures in elderly patients. J Bone Joint Surg Am 1997;79A:826–832.

· Faierman E, Wang J, Jupiter JB. Secondary ulnar nerve palsy in adults after elbow trauma: a report of two cases. J Hand Surg Am 2001; 26A:675–678.

· Frankle MA, Herscovici D Jr, DiPasquale TG, et al. A comparison of open reduction and internal fixation and primary total elbow arthroplasty in the treatment of intraarticular fractures of the distal humerus in women older than 65 years. J Shoulder Elbow Surg 1999;9:455.

· Frankle MA, Herscovici D Jr, DiPasquale TG, et al. A comparison of open reduction and internal fixation and primary total elbow arthroplasty in the treatment of intraarticular distal humerus fractures in women older than age 65. J Orthop Trauma 2003;17:473–480.

· Gambirasio R, Riand N, Stern R, Hall JE. Total elbow replacement for complex fractures of the distal humerus: an option for the elderly patient. J Bone Joint Surg Br 2001;83B:974–978.

· Holmes JC, Skolnick MD, et al. Untreated median-nerve entrapment in bone after fracture of the distal end of the humerus: postmortem findings after forty-seven years. J Bone Joint Surg Am 1979;61A: 309–310.

· Huang TL, Chiu FY, Chuang TY, et al. The results of open reduction and internal fixation in elderly patients with severe fractures of the distal humerus: a critical analysis of the results. J Trauma 2005; 58:62–69.

· Kamineni S, Morrey BF. Distal humeral fractures treated with noncustom total elbow replacement. J Bone Joint Surg Am 2004;86A: 940–947.

· Kamineni S, Morrey BF. Distal humeral fractures treated with noncustom total elbow replacement: surgical technique. J Bone Joint Surg Am 2005;87A:41–50.

· Lee KT, Lai CH, Singh S. Results of total elbow arthroplast1y in the treatment of distal humerus fractures in elderly Asian patients. J Trauma 2006;61:889–892.

· Mohan K. Myositis ossificans traumatica of the elbow. Int Surg 1972;57:475–478.

· Pajarinen J, Bjorkenheim JM. Operative treatment of type C intercondylar fractures of the distal humerus: results after a mean followup of 2 years in a series of 18 patients. J Shoulder Elbow Surg 2002; 11:48–52.

· Parsons M, O'Brien R, Hughes JS. Elbow hemiarthroplast1y for acute and salvage reconstruction of intra-articular distal humerus fractures. Tech Shoulder Elbow Surg 2005;2:87–97.

· Ray PS, Kakarlapudi K, Rajsekhar C, et al. Total elbow arthroplast1y as primary treatment for distal humeral fractures in elderly patients. Injury 2000;31:687–692.

· Thompson HC 3rd, Garcia A. Myositis ossificans: aftermath of elbow injuries. Clin Orthop Relat Res 1967;50:129–134.

· Zhao J, Wang X, Zhang Q. Surgical treatment of comminuted intraarticular fractures of the distal humerus with double tension band osteosynthesis. Orthopedics 2000;23:449–452.



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