Principles of Ambulatory Medicine, 7th Edition

Chapter 21

Somatization

Robert P. Roca

Illness Behavior and Somatization

People who consult health care practitioners are expected to have discernible pathologic or pathophysiologic abnormalities (i.e., disease) accounting for their symptoms. The magnitude of their complaints and the associated disability are expected to be proportional to the disease diagnosed. They are supposed to pursue and cooperate with medical care and to resume normal social functioning as soon as possible. This sequence of responses is called normal illness behavior (1).

Sometimes there is a discrepancy between diagnosable disease and the magnitude and duration of symptoms and disability. Patients may complain of weakness or pain in the absence of objective findings. They may have pseudoseizures. They may visit their health care practitioners repeatedly with fears of having acquired immunodeficiency syndrome (AIDS) despite several negative human immunodeficiency virus (HIV) serology results and normal physical examinations. Such responses are examples of abnormal illness behavior.

Explaining discrepancies between objective evidence of disease and the subjective experience of symptoms is a major concern of psychosomatic medicine and an active area of research. It is speculated that “unexplained somatic symptoms” may in some cases result from functional disturbances of the central nervous system that may be possible to demonstrate in the future using functional central nervous system (CNS) imaging techniques (2). It is also believed that some patients with unexplained somatic symptoms may be manifesting somatization, a phenomenon in which physical symptoms are linked to psychological factors or conflicts. Its mechanisms are incompletely understood, but factors promoting somatization can often be discovered in individual cases.

Why Patients Somatize

Explanations of somatization come from at least four distinct perspectives: Somatization may be viewed as a product of disease, a manifestation of personality, a modeled or reinforced behavior, or an understandable product of a patient's life story. Each perspective calls for different observations and illuminates different aspects of the phenomenon of somatization.

Somatization as a Symptom of Disease

Somatization may occur as a symptom of a psychiatric disorder, particularly major depression, panic disorder, schizophrenia, or dementia. Sometimes somatic symptoms are the only complaints that patients with these conditions present to their health care practitioners (3).

As noted above, unexplained physical symptoms may in some cases be caused by as yet uncharacterized “functional disturbances of the nervous system” (2); this is a speculative proposal without firm empirical support at this time. There is no doubt that unexplained symptoms may also be caused by clear-cut medical conditions that have simply not yet been diagnosed—even when the symptoms seem to be expressing a psychological conflict or need. Studies of one subset of somatizing patients—those originally diagnosed as hysterics—have shown that up to 30% may ultimately be found to have medical or neurologic disorders

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that, in retrospect, explain the presenting hysterical symptoms (4). On the other hand, a general tendency to complain of somatic symptoms may be negatively correlated with the presence of particular specific pathologic entities (e.g., coronary artery disease [CAD]) (5). Furthermore, the greater the number of unexplained somatic symptoms (e.g., pain complaints), the greater the likelihood of a diagnosable psychiatric disorder such as major depression (6).

Somatization as a Manifestation of Personality

The concept of personality implies enduring attitudes and habitual patterns of response. Personalities may be viewed as approximations of ideal prototypes (e.g., histrionic, obsessive-compulsive) or as clusters of individual traits (e.g., dependency, assertiveness), as discussed inChapter 23. Somatization has been associated with personality viewed in both of these ways. Patients with a histrionic or an obsessive-compulsive personality type may be predisposed to develop, respectively, somatization disorder or hypochondriasis (see later sections on these disorders). Patients with prominent traits of introspectiveness (i.e., tendancy to devote diffuse attention to thoughts and feelings about the self) (7) or neuroticism (i.e., emotionally unstable, vulnerable to stress, and self-conscious) (8) are particularly likely to experience and report unexplained physical symptoms.

Somatization as Reinforced Behavior

Somatization may be viewed as behavior modeled or reinforced by the patient's environment (9). This perspective prompts exploration for a history of similar symptoms in the patient or a close contact and encourages a search for evidence of social benefit associated with the patient's current symptoms.

Case Example

A 20-year-old woman was evaluated in the office for back pain. The physical examination was unimpressive, and an extensive workup was unrevealing. Discussions with the family disclosed that the patient's father was about to lose his disability income and that financial hardship was expected. Environmental reinforcements related to possibly becoming eligible for disability, thereby ameliorating the family's anticipated financial crisis, probably contributed to the continuation of this patient's symptoms.

Somatization and the Life Story

Somatization may be viewed as a maladaptive but understandable expression of, or response to, difficulties originating in early life experiences. This perspective is at least as old as the concept of “hysterical conversion,” introduced in 1795 by John Ferrier and elaborated upon by Freud and Breuer in the late 19th century (10), and its validity is supported by abundant evidence that persons with histories of childhood abuse have higher rates of unexplained physical symptoms and medical services utilization (11,12). Although particular formulations are difficult to prove in individual cases, they may help clinicians comprehend and manage illness behavior that is otherwise irritating and baffling. For example, patients who suffer parental abuse and neglect may carry into adulthood potent mixtures of hostility and dependency that are activated in relationships with health care practitioners. Such patients may develop physical symptoms without diagnosable disease and pursue unrevealing medical evaluations. Sometimes hostile and demanding, they may demean the competence and the commitment of their health care practitioners, even as they crave medical attention and insist on even more care. Such behaviors may be seen as expressions of angry disappointment with their earliest caretakers, who did not adequately meet their dependency needs, now displaced onto the practitioner. Other patients may have childhood memories of experiencing attention and caring only when they were ill, or they may have come from families or cultures in which it was customary to express emotional distress as physical symptoms. Such formulations may help clinicians respond to such patients without anger and permit the development of a constructive doctor–patient relationship. Other formulations of this type are discussed elsewhere (13).

Reaching a Working Formulation and Making a Diagnosis

Thus the development of a working formulation requires consideration of the relative merits of the four distinct explanatory points of view in a particular case. Once the clinician has determined that the unexplained symptoms are not because of a previously undiagnosed medical disorder, there are four fundamental questions:

  1. Does the patient have a psychiatric disorder of which somatization is a symptom?
  2. Does the patient have personality traits or a personality type predisposing to somatization?
  3. Is the patient's abnormal illness behavior modeled or reinforced by some aspect of the patient's environment?
  4. Is this behavior empathically understandable as a product of the patient's unique life history and current predicament?

As shown later, the working formulation often carries specific therapeutic implications.

Somatizing patients may fall into defined diagnostic groups (Table 21.1). The diagnostic classification of somatization is presently under review, and there are proposals

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for radical revision (14). Despite these controversies, there is agreement that unexplained somatic symptoms account for a substantial proportion of both primary care and specialist visits and that the formal somatoform disorders (e.g., conversion disorder, somatization disorder, hypochondriasis) and factitious disorders account for only a small proportion of these cases (14). Many more patients have incomplete forms of these conditions (e.g., somatoform disorder not otherwise specified; undifferentiated somatoform disorder), adjustment disorders with anxiety or depression partly manifested by somatic symptoms, or actual medical conditions whose manifestations are influenced by psychosocial factors (see Psychological Factors Affecting Medical Conditions section).

TABLE 21.1 Psychiatric Disorders Associated with Somatization

Mental disorders
Mood disorders, especially major depression
Anxiety disorders, especially panic disorder
Schizophrenia
Personality disorders, especially histrionic, dependent, and obsessive-compulsive
Adjustment disorder with anxiety or depression
Psychological factors affecting medical conditions
Somatoform disorders
Somatization disorder
Undifferentiated somatoform disorder
Hypochondriasis
Conversion disorder
Somatoform pain disorder
Body dysmorphic disorder
Disorders with voluntary symptom production
Factitious disorder with physical symptoms
Malingering

This chapter reviews adjustment disorders, psychological factors affecting medical conditions, the primary somatoform disorders, and disorders in which symptom production is deliberate. Mood disorders (Chapter 24), anxiety disorders (Chapter 22), schizophrenia (Chapter 25), and personality disorders (Chapter 23) are discussed in detail elsewhere in this book.

Adjustment Disorders

Description

Adjustment disorders are reactive emotional states resulting from difficulty meeting the demands of life. Patients feel overwhelmed by illness, marital discord, or other problems and become demoralized. While adjustment disorders are classified according to the patient's predominant psychological symptomatology (e.g., depression, anxiety), sometimes the patient's most prominent complaints are somatic symptoms. It is in these cases that patients with adjustment disorders are most likely to present to their general health providers. This is because (1) somatic complaints legitimize a visit to the doctor and (2) emotional distress precipitated by stressful experiences can amplify bodily symptoms and lead patients to become convinced that they are seriously ill. When emotional and somatic symptoms arise in response to psychosocial problems, a diagnosis of adjustment disorder should be considered (see Table 24.1 in Chapter 24).

Case Example

A shy 26-year-old parochial school teacher was evaluated for dizziness, abdominal cramps, nausea, excessive urination, and a sensation of fullness in the bladder. When physical examination and laboratory tests revealed no physiologic disturbance, a more detailed history was taken. It showed that the patient's symptoms began shortly after a confrontation with his school principal over his attempt to organize a teacher's union and his criticism of school policies. (Diagnosis: adjustment disorder with anxiety and physical symptoms.)

Patients such as this one are often unaware of the relationship between their psychological distress and somatic symptoms.

As illustrated in the following example, diagnosis may be difficult when the symptoms precipitated by psychosocial stress resemble those of a patient's established disease process.

Case Example

A 54-year-old widow recovering from a myocardial infarction complained to her primary care practitioner of fatigue, breathlessness, and pleuritic chest pain unrelated to exertion. Her physical examination and electrocardiographic findings were unchanged. Questioning revealed that the patient was forced to leave her job after her heart attack and was barely able to afford necessary medications. She tearfully revealed that, although her son had offered to help pay for her medications, her daughter-in-law hinted that they could not really afford to help. This proud and formerly self-sufficient woman, who was initially reluctant to accept any help, now felt even more vulnerable and inadequate, and she acknowledged that the periodic symptoms in her chest invariably occurred while she was thinking about these difficulties. (Diagnosis: adjustment disorder with mixed emotional features and physical symptoms.)

In this case, emotional distress produced symptoms suggesting cardiac disease. The correct diagnosis was made when the relevant history was elicited.

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Management

Three strategies are important in evaluating patients who may have adjustment disorders:

  1. Elicit the relevant history.Asking the patient open-ended questions such as, “How are things at home (or at work)?” invites patients to expand on their history and often reveals potential sources of psychosocial distress. Most patients are grateful for a clinician's interest, respect time limits, and go on to solve the precipitating problem themselves. Even before the practitioner has taken a psychosocial history, patients may provide verbal and nonverbal cues suggesting distress (e.g., saying “Things aren’t the way they used to be,” wringing hands and looking away when describing a new somatic symptom) (15). Many patients who are initially reluctant to acknowledge psychosocial distress eventually open up in response to gentle, persistent encouragement from a trusted clinician.
  2. Rule out major depression.Patients who attribute their low mood to identifiable psychosocial stressors do not necessarily have an adjustment disorder. Such symptoms as persistently depressed mood, loss of interest in usual activities, poor concentration, reduced energy, diminished appetite, and disturbed sleep suggest a major depressive disorder for which antidepressant medication usually is indicated (see Chapter 24). The presence of an apparent psychosocial precipitant should never deter the physician from inquiring about such symptoms.
  3. Temper the workup.Patients should be examined and appropriate laboratory tests ordered; however, extensive workups to exclude improbable diagnoses should be undertaken only after careful consideration and after allowing some time to elapse, because such workups may imbed patients in the sick role and prolong their disability.
  4. Work with the patient to understand and accept the link between somatic symptoms and psychosocial stress.Patients do not like to hear the doctor say “It's all in your head.” But most patients can accept the proposal that stressful life events can produce or exacerbate physical discomfort, particularly when the physician has listened closely to their complaints, examined them carefully, and ordered appropriate laboratory tests, if indicated. Sometimes it is helpful to offer a simple illustration of how emotional stimuli can lead to physical manifestations (“You have noticed how the hair on a cat's back will stand up when the cat sees a dog. In a similar way, we may undergo physiological changes in response to stress, and these changes can make us sick.”). This is an example of what has been called “the coconstruction of the meaning of distress,” a critical task of the clinical encounter in these cases (16).

The identification of a psychosocial basis for patients’ somatic complaints is often sufficient to allow them to marshal their own resources for coping (17). When these measures fail, the patient may need goal-focused short-term counseling (see Chapter 20). In selected cases, short-term prescription of anxiolytic or hypnotic medications may be helpful.

There have been only a few reports of outcomes of minor mood disturbances managed by generalists (17, 18, 19). From these studies, the following tentative conclusions can be stated:

  • A large proportion of patients get better after just one office visit. Most often, this visit includes empathic listening, a partial physical examination, and reassurance that the patient does not have a serious physical problem.
  • Short-term prescribing of drugs for anxiety or insomnia may not increase the proportion of patients who show significant improvement (about two thirds of patients) on re-evaluation after 1 month (18). This conclusion derives from a single careful study in which patients with minor mood disturbances were allocated at random to receive brief counseling plus a benzodiazepine drug or brief counseling only.

Several practical considerations regarding longitudinal management are suggested by these findings:

  • It is generally prudent to determine the impact of an initial visit on a patient's distress (by a brief telephone or office followup visit within 1 week) before considering a psychotropic drug for an adjustment disorder.
  • About one third of patients who seem to have an adjustment disorder do not respond to the aforementioned strategies. At followup visits, such patients should be re-interviewed systematically to look for evidence of panic disorder (Chapter 22), major depression (Chapter 24), alcoholism (Chapter 28), chemical dependency (Chapter 29), and domestic violence (Chapter 28) affecting themselves or a member of their household, or one of the somatoform disorders described later in this chapter. For all of these problems, specific treatment in addition to office psychotherapy is indicated.

Psychological Factors Affecting Medical Conditions

Description

Psychological factors can exacerbate somatic symptoms caused by a concurrent physical disorder. The resulting symptoms are sometimes called psychophysiologic. Table 21.2 lists the most common conditions in which such symptoms may occur. When the features listed in Table 21.3 are present, the diagnosis from the Diagnostic and

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Statistical Manual of Mental Disorders, 4th Edition (DSM-IV)
, is Psychological Factors Affecting Medical Condition.

TABLE 21.2 Common Conditions in Which Psychophysiologic Symptoms Are Important

Physiologic System

Symptomatic Condition

Chapter with Further Information

Cardiovascular

Migraine headache

87

Vasovagal syndrome (fainting)

89

Hypertension (usually asymptomatic)

67

Supraventricular tachycardia

64

Angina

62

Gastrointestinal

Irritable bowel syndrome

44

The following symptoms may occur singly or together: anorexia, nausea, vomiting, abdominal cramps, diarrhea, constipation, aerophagia, acid-peptic symptoms

42,43,44,45,46

Genitourinary

Menstrual disturbance

101

Difficulties in micturition: frequency (in both sexes),

36, 53

retention (females), hesitancy (in males)

Sexual disorders

6

Dyspareunia

Anorgasmia

Inhibited sexual excitement

Delayed ejaculation, premature ejaculation

Musculoskeletal

Pain secondary to increased muscle tension: occipital or bitemporal headaches, backaches, myalgia in various muscle groups

71, 74, 87

Fatigue

Tremor

90

Rheumatoid arthritis

77

Respiratory

Hyperventilation syndrome

22

Bronchospasm

60

Dyspnea

59

Skin

Hyperhidrosis

Pruritus

Most of the conditions listed in Table 21.2 may occur with or without a significant psychological component; detailed descriptions of most of these conditions are found elsewhere in this book, as indicated in the table. For a patient's symptoms to be interpreted as psychophysiologic, they should bear a temporal relationship to a stressful life situation and should subside when the stressful situation abates.

TABLE 21.3 Diagnostic Criteria for Psychological Factors Affecting Physical Condition

1. A general medical condition (coded on axis III) is present.

2. Psychological factors adversely affect the general medical condition in one of the following ways:

1. The factors have influenced the course of the general medical condition as shown by a close temporal association between the psychological factors and the development or exacerbation of, or delayed recovery from, the general medical condition.

2. The factors interfere with the treatment of the general medical condition.

3. The factors constitute additional health risks for the individual.

4. The factors elicit stress-related physiologic responses that precipitate or exacerbate symptoms of a general medical condition (e.g., chest pain or arrhythmia in a patient with CAD).

Reprinted with permission from Diagnostic and statistical manual of mental disorders. 4th Edition. Washington, DC: American Psychiatric Association, 1994.

Conversion symptoms (see Conversion Disorder section) are differentiated from psychophysiologic symptoms by the absence of a pathophysiologic condition in the former. Psychophysiologic problems are closely related to adjustment disorders, but they are distinguishable from them in that the somatic symptoms are caused by a recognized pathophysiologic condition and the same symptoms may occur in the absence of psychosocial stressors. This diagnosis is also used when psychological factors interfere with the treatment of a general medical condition (e.g., when strong denial of illness interferes with adherence to medication regimens).

Management

When initiation or exacerbation of a physical condition is related to environmental stressors, management is the same as that described for adjustment disorder.

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Somatoform Disorders

As a group, the somatoform disorders are characterized by the occurrence of physical symptoms that lack an organic basis and are linked, by positive evidence or strong presumption, to psychological factors or conflicts. They may be acute or chronic, mild or severely disabling. Because patients with these disorders believe themselves to be physically ill, they are treated primarily by nonpsychiatrists and generally do not accept psychiatric referral. In addition to the management strategies described here, the strategies for managing abnormal illness behavior, described in Chapter 20, usually are helpful.

Somatization Disorder

Description

The best-studied disorder in this group is somatization disorder, formerly known as hysteria or Briquet syndrome. This is a chronic disorder beginning before 30 years of age in which the patient seeks treatment for multiple, widely distributed symptoms lacking any known pathologic basis or pathophysiologic mechanism. To meet DSM-IV criteria for this disorder, the patient must have a history of at least eight such symptoms, drawn from the four symptom subgroups listed in Table 21.4: Pain symptoms (at least four), gastrointestinal (GI) symptoms (two or more), sexual symptoms (at least one), and pseudoneurologic symptoms (at least one). Accurate diagnosis often requires review of old records and careful history-taking to determine that a sufficient number of unexplained symptoms have been presented for evaluation and treatment or have caused the patient to take over-the-counter (OTC) remedies or alter his or her lifestyle. Seven symptoms are especially useful in screening: shortness of breath without exertion, dysmenorrhea, burning sensations in sexual organs, difficulty swallowing (lump in throat), amnesia, vomiting, and pain in extremities. The presence of three of these symptoms without adequate physical explanation identifies somatization disorder with a sensitivity of 87% and specificity of 95% (20). Symptoms are often described in dramatic and colorful terms, but details tend to be vague and contradictory.

TABLE 21.4 Diagnostic Criteria for Somatization Disorder

1. History of many physical complaints beginning before 30 years of age, occurring over a period of several years, and resulting in treatment being sought or significant impairment in social or occupational functioning.

2. Each of the following criteria must have been met at some time during the course of the disorder.

1. Four pain symptoms: A history of pain related to at least four different sites or functions (such as head, abdomen, back, joints, extremities, chest, rectum, during sexual intercourse, during menstruation, or during urination)

2. Two GI symptoms: A history of at least two GI symptoms other than pain (such as nausea, diarrhea, bloating, vomiting other than during pregnancy, or intolerance of several different foods)

3. One sexual symptom: A history of at least one sexual or reproductive symptom other than pain (such as sexual indifference, erectile or ejaculatory dysfunction, irregular menses, excessive menstrual bleeding, vomiting throughout pregnancy)

4. One pseudoneurologic symptom: A history of at least one symptom or deficit suggesting a neurologic disorder not limited to pain (conversion symptoms such as blindness, double vision, deafness, loss of touch or pain sensation, hallucinations, aphonia, impaired coordination or balance, paralysis or localized weakness, difficulty swallowing, difficulty breathing, urinary retention, seizures; dissociative symptoms such as amnesia, or loss of consciousness other than fainting)

3. Either of the following must have been met:

1. After appropriate investigation, each of the symptoms in criterion B cannot be fully explained by a known general medical condition, or the direct effects of a substance (e.g. a drug of abuse, a medication).

2. When there is a related general medical condition, the physical complaints or resulting social or occupational impairment are in excess of what would be expected from the history, physical examination, or laboratory findings.

4. The symptoms are not intentionally produced or feigned (as in Factitious Disorder or Malingering).

Reprinted with permission from Diagnostic and statistical manual of mental disorders. 4th Edition. Washington, DC: American Psychiatric Association, 1994.

Somatization disorder occurs in 0.2% to 2.0% of women in the general population, but it is much more common among women seen in clinical settings (21). It is rare in men. Histrionic personality traits may be present. Somatization disorder occurs in 10% to 20% of female first-degree relatives of women with somatization disorder; alcoholism and antisocial personality disorder occur frequently among their male relatives.

Common complications include substance abuse and iatrogenic illness. One classic study found that women with hysteria undergo more than three times as many operations as control women and lose, by weight, more than three times the mass of organs (22).

The disorder is chronic. In a retrospective study of 49 patients, almost 70% of women were still symptomatic 15 years after diagnosis (23). However, the mortality rate of women with somatization disorder is the same as that of normal women (24), and the likelihood of developing another medical or psychiatric disorder explaining the symptoms is only 10% in long-term followup (25).

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Case Example

A 43-year-old married woman was referred for psychiatric evaluation by her internist who, noting her presentation with ill-defined symptoms, was requesting help with management. She complained of generalized muscle aching and periodic sensations throughout her body described as “how you feel when someone scratches his fingers on a blackboard.” She also complained of skin lesions on her back and stated that she was hypothyroid and suffered from a chronic urinary tract infection. Her history included tonsillectomy, groin lymph node biopsy (twice), hysterectomy, bladder suspension (twice), rectocele repair, removal of abdominal adhesions, multiple cystoscopies, appendectomy, and removal of a tongue papilloma. The patient stated she had Ménière disease and episodes of sudden shortness of breath. She also carried a diagnosis of fibrositis, for which she had taken steroids in the past, and restless legs syndrome. She had stopped having sexual intercourse with her husband because of “pain that 10 gynecologists could not cure.” Her current medicines included a benzodiazepine, a nonsteroidal anti-inflammatory agent, and a belladonna alkaloid. She mentioned that she had always been ill and that she hated men. Her psychosocial history included marriage to an alcoholic who abused her and a positive family history of suicide. In presenting her symptoms, the patient was extremely vague and interjected facts about her emotional life with an inappropriate laugh. She believed that her symptoms were caused by food allergy. She had stopped eating and at the time of her initial visit to her internist had ingested only distilled water for 4 days. Physical examination and laboratory test results were normal.

Management

Because these patients adhere firmly to the idea that they are physically ill, they usually do not accept psychiatric referral, and their treatment lies largely in the hands of nonpsychiatrists. Guidelines for management include the following:

  1. Review past medical recordsto determine the range of symptomatic complaints brought to health care practitioners and the adequacy of documented evaluations.
  2. Respond to physical symptoms appropriatelyby taking a careful history and doing the appropriate physical examination. Recognize that the history, as a diagnostic test, will have comparatively low specificity for physical disease (see Chapter 2) and that questioning techniques that diminish the likelihood of false positive findings, such as the use of open-ended and nonleading questions (see Chapter 3), are particularly important for such patients. Avoid hospitalizations, specialty consultations, and invasive laboratory tests unless objective indications exist (see Managing Abnormal Illness Behavior, in Chapter 20).
  3. Review the four explanatory perspectives(see Why Patients Somatize) for factors that might be promoting the development of somatization: psychiatric disease (especially major depression), personality disorder (especially histrionic type), behavioral model (e.g., sick family members), and environmental reinforcers (e.g., increased attention from parents) supporting the sick role, as well as aspects of the patient's life story (e.g., poor attention to early childhood dependency needs) that make the patient's symptoms (e.g., endless recitation of complaints that keep the patient under very close medical scrutiny) understandable. When possible, address the apparently etiologic factors in the treatment plan (e.g., treat major depression with antidepressants; counsel family members to give attention for healthy behavior but to refrain from rewarding illness behavior).
  4. Work with the patient to understand and accept the link between somatic symptoms and psychosocial stress(see above underAdjustment Disorder, Management).
  5. Do not expect symptoms to remit entirely, and do not promise cure or complete resolution of symptoms.
  6. Promote the performance of normal function despite symptoms, and praise the patient for carrying out specific activities and for being productive in the face of discomfort.
  7. Assure the patient of your continuing availability, and schedule regular, brief visitsso that access to medical attention does not require the development of new symptoms.
  8. Help the familyof the patient recognize that, despite the abundance and persistence of symptoms, no serious disease has been found, and encourage them to support a strategy that de-emphasizes expensive and elaborate diagnostic tests and stresses maintenance of function in the face of symptoms.
  9. Try “mining for gold”(26). Because these patients focus on physical symptoms, which usually are not explained by physical disease and do not resolve with treatment, the clinician is likely to spend each visit investigating the physical symptoms of concern, performing unrevealing diagnostic tests, and becoming frustrated. By spending some time during each visit “mining for gold” (i.e., getting to know in depth the person who is the patient) the clinician may discover previously unrecognized admirable and likeable aspects of the patient, forge a mutually satisfactory practitioner–patient relationship, and be able to facilitate more effectively the patient's maintenance of health and functional status despite symptoms.

The usefulness of measures such as these in the management of somatization disorder has been demonstrated in a randomized, controlled study (27).

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Undifferentiated Somatoform Disorder and Multisomatoform Disorder

Undifferentiated somatoform disorder is a residual category designed to accommodate patients who do not fully meet criteria for somatization disorder (Table 21.5). Symptoms must be present for at least 6 months for the diagnosis to be made. There need be no identifiable precipitant. Although the disorder has not been well studied, it is believed to be much more common than somatization disorder. Its prognosis and clinical course are unknown.

TABLE 21.5 Diagnostic Criteria for Undifferentiated Somatoform Disorder

1. One or more physical complaints (e.g., fatigue, loss of appetite, GI or urinary complaints)

2. Either of the following:

1. After appropriate investigation, the symptoms cannot be explained by a known general medical condition or pathophysiologic mechanism (e.g., the effects of injury, medication, drugs, or alcohol).

2. When there is a related general medical condition, the physical complaints or resulting social or occupational impairment are grossly in excess of what would be expected from the physical findings.

3. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.

4. The duration of the disturbance is at least 6 months.

5. The disturbance is not better accounted for by another mental disorder (e.g., another somatoform disorder, sexual dysfunction, mood disorder, anxiety disorder, sleep disorder, or psychotic disorder).

6. The symptoms are not intentionally produced or feigned (as in Factitious Disorder or Malingering).

Reprinted with permission from Diagnostic and statistical manual of mental disorders. 4th Edition. Washington, DC: American Psychiatric Association, 1994.

Multisomatoform disorder is a term that does not appear in DSM-IV. It has been proposed as an alternative to “undifferentiated somatoform disorder” for patients with a 2-year history of apparent somatoform symptoms and at least three current somatoform symptoms, reported from a 15-symptom checklist (28). Of 1,000 participants in the Primary Care Evaluation of Mental Disorders (PRIME-MD) (29) study, 82 (8.2%) met criteria for this condition. These patients had significantly greater numbers of disability days and doctor visits as well as impairments in health-related quality of life and were far more likely than patients with other psychiatric conditions to be judged “difficult” by their physicians.

Although there are no studies of treatment for these specific disorders, there is evidence that techniques useful in full-fledged somatization disorder (see Somatization Disorder, Management) are helpful for long-term somatizing patients who do not meet all of the diagnostic criteria for somatization disorder (30).

TABLE 21.6 Diagnostic Criteria for Conversion Disorder

1. One or more symptoms or deficits affecting voluntary motor or sensory function suggesting a neurologic or general medical condition.

2. Psychological factors are judged to be associated with the symptom or deficit because the initiation or exacerbation of the symptom or deficit is preceded by conflicts or other stressors.

3. The symptom or deficit is not intentionally produced or feigned (as in Factitious Disorder or Malingering).

4. The symptom of deficit cannot, after appropriate investigation, be fully explained by a neurologic or general medical condition, and is not a culturally sanctioned behavior or experience.

5. The symptom or deficit causes clinically significant distress or impairment in social, occupational, or other important areas of functioning; or warrants medical evaluation.

6. The symptom or deficit is not limited to pain or sexual dysfunction, does not occur exclusively during the course of somatization disorder, and is not better accounted for by another mental disorder.

Reprinted with permission from Diagnostic and statistical manual of mental disorders. 4th Edition. Washington, DC: American Psychiatric Association, 1994.

Conversion Disorder

Description

Conversion disorder is a disorder in which an unexplained loss or alteration of body functioning develops in the presence of evidence that the symptoms solve or express a psychological conflict or need (Table 21.6). The symptoms often simulate neurologic disease but conform to the patient's notion of body function rather than to the rules of neuroanatomy, and medical evaluation yields no evidence of diagnosable disease. Amnesia, aphonia, blindness, paralysis, numbness, and seizures are among the most common conversion symptoms. The disorder probably occurs more often in women than in men, and it usually begins in adolescence or early adulthood. Patients may have histrionic or dependent personalities and may exhibit remarkable serenity (“la belle indifference”) in the face of their impairments.

Conversion disorder is unique among DSM-IV somatoform disorders in that the definition not only describes the diagnostic criteria but also proposes psychological mechanisms as explanations. A mechanism called secondary gain is invoked when unexplained symptoms allow the patient to avoid onerous tasks or undesirable duties (see Somatization as Reinforced Behavior).

Case Example

A 15-year-old girl with a history of migraine headache and transient visual field cuts was evaluated for a new visual field cut that had developed without headache over the previous 24 hours. On examination, the visual defect was found to “split the macula.”

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At the time of psychiatric interview she revealed that she expected her visual problems to prevent her from obtaining a driver's license when she turned 16. She went on to say that she was afraid to drive, that no other woman in her family drove, and that she would be called upon by everyone to provide transportation. She was referred to a pediatric neurology service, where she received physical therapy and daily psychotherapy. Her field defect resolved.

A second mechanism, primary gain, is invoked when conversion symptoms appear to resolve an internal conflict created by a feeling, impulse, or wish that the individual finds frightening or morally unacceptable.

Case Example

A 50-year-old man was admitted to the hospital because of amnesia. He spoke normally and was otherwise neurologically intact, although he could not remember his name or any other details of personal history. After about 24 hours he began speaking freely about anger related to the recent dissolution of his marriage. Particularly upsetting had been news that his boss was dating his wife. Immediately before the development of amnesia he had thought that he might be provoked to violence if he discovered them together. His amnesia completely resolved in 2 days, and he was discharged from the hospital. He briefly participated in outpatient psychotherapy. The working formulation was that the amnesia had served to remove unacceptable violent intentions from his awareness and to protect him from acting on them.

Acute conversion symptoms have a good prognosis for recovery, especially if the patient has no other psychiatric disorder.

Management

Guidelines for the treatment of patients with conversion disorder include the following:

  1. Be certain that the patient has had an adequate medical evaluation, because some patients with conversion symptoms have an undiagnosed medical disorder (4).
  2. Review the various explanatory perspectives for factors that might be promoting the development of conversion symptoms(see Why Patients Somatize): e.g., environmental reinforcers supporting the sick role (e.g., not having to drive) or aspects of the patient's life story (e.g., violent feelings toward an abusive alcoholic father) that make the symptoms understandable (e.g., visual impairment that prevents driving; paralysis of the hand that prevents violent revenge against the father). When possible, address specific interventions to the etiologic factors identified (e.g., refer the angry child of an alcoholic to Al-Anon).
  3. Emphasize the evidence that no serious disease is present, and express optimism about the prospect of full recovery. Consider physical therapy or some other physical rehabilitative intervention to help the patient save faceduring recovery.
  4. Do not bluntly confront the patient with the psychological origins of the symptoms, but stress that emotional factors can exacerbate such problems. Review the patient's current life circumstances and difficulties, and consider undertaking a course of short-term counseling (see Chapter 20).

Hypochondriasis

Description

Hypochondriacal concerns that are relieved by evaluation, explanation, and reassurance are common in medical practice. Hypochondriasis, however, is a chronic disorder in which unrealistic interpretation of physical symptoms leads the patient to fear the presence of a serious illness in the face of repeated reassurances based on adequate medical evaluation (Table 21.7). Onset is usually in the third decade but may occur later. Both sexes are equally affected. Obsessive-compulsive personality traits are often observed. Anxiety, depression, drug dependence, and iatrogenic disease are common complications. The disorder tends to be chronic, with waxing and waning intensity. Symptomatic exacerbations occur in response to psychosocial stresses and to stimuli that provoke bodily preoccupation and fear of disease.

TABLE 21.7 Diagnostic Criteria for Hypochondriasis

1. Preoccupation with fears of having, or the idea that one has, a serious disease based on the person's misinterpretation of bodily symptoms.

2. The preoccupation persists despite appropriate medical evaluation and reassurance.

3. The belief (in criterion A) is not of delusional intensity (as in Delusional Disorder, Somatic type) and is not restricted to a circumscribed concern about appearance (as in Body Dysmorphic Disorder).

4. The preoccupation causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

5. The duration of the disturbance is at least 6 months.

6. The preoccupation does not occur exclusively during the course of generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, major depressive episode, separation anxiety, or another somatoform disorder.

Specify if with poor insight: if, for most of the time during the current episode, the person does not recognize that the concern about having a serious illness is excessive or unreasonable.

Reprinted with permission from Diagnostic and statistical manual of mental disorders. 4th Edition. Washington, DC: American Psychiatric Association, 1994.

Case Example

A 30-year-old accountant had always been self-conscious about his physical appearance, a concern that he attempted to allay by weight lifting. After his father died of a heart attack, he became concerned that he might have heart disease and was fearful about the implication of insignificant chest pains. He also worried about his blood pressure, which was transiently elevated at the time of his yearly physical examinations. His most recent examination revealed insignificant liver enzyme elevations, a finding over which he fretted for weeks. Despite these concerns, he rarely missed a day of work. He was not sure that he did not have a serious disease but thought he had best trust his health care provider.

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Management

Because patients with hypochondriasis believe that they are physically ill, they often refuse psychiatric treatment. Guidelines for management by generalists are similar to those for other chronic somatoform disorders and include the following:

  1. Review past medical recordsto determine the range of symptomatic complaints brought to health care practitioners and the adequacy of documented evaluations.
  2. Respond to physical symptoms appropriatelyby taking a careful history and doing the appropriate physical examination. Reassurances cannot be given to the patient if the physical complaints are not investigated. At the same time, recognize that the history, as a diagnostic indicator, may have comparatively low specificity for physical disease (see Chapter 2), and that questioning techniques that diminish the likelihood of false positive findings, such as the use of open-ended and nonleading questions (see Chapter 3), are particularly important in such patients. Avoid hospitalization, inappropriate specialty consultations, and invasive laboratory tests unless objective indications exist (see Managing Abnormal Illness Behavior, in Chapter 20).
  3. Review the four explanatory perspectives(see Why Patients Somatize) for factors that might be promoting hypochondriasis: psychiatric illness (especially major depression and anxiety disorders), personality disorder (especially obsessive-compulsive type), behavioral models or environmental reinforcers supporting the role (e.g., family members who were excessively concerned about patient's childhood health and lavished attention in response to minor ailments), and aspects of the patient's life story (e.g., religious upbringing with particular emphasis on sexual morality and punishment of sinners) that make the symptoms empathically understandable (e.g., hypochondriacal fear of AIDS in a man with repeatedly negative HIV antibody tests who had a single extramarital encounter 5 years before). When possible, address specific interventions to etiologic factors identified (e.g., counsel family members to give attention for healthy behavior but refrain from rewarding illness behavior). It is especially important to consider treating concurrent major depression and anxiety disorders with antidepressant medications, because the amelioration of major mood and anxiety symptoms often greatly improves the receptivity of hypochondriacal patients to reassurance about their physical health.
  4. Do not expect symptoms to remit entirely, and do not promise cure or complete resolution of symptoms(see Managing Abnormal Illness Behavior, in Chapter 20).
  5. Promote the performance of normal functions despite symptoms, and praise the patient for carrying out specific activities and being productive in the face of discomfort.
  6. Reassure the patient of your continuing availability, and schedule regular, brief visitsso that access to medical attention does not depend on the development of new symptoms.
  7. Work with the patient to understand and accept the link between somatic symptoms and psychosocial stress(see above underAdjustment Disorder, Management).
  8. Help the familyof the patient recognize that despite the persistence of symptoms no serious disease has been found, and encourage them to support a strategy de-emphasizing expensive and elaborate diagnostic tests and stressing maintenance of function in the face of symptoms.
  9. Try “mining for gold”(26) (see above under Somatization Disorder, Management).
  10. Some patients may accept short-term counseling(see Chapter 20). Formal cognitive-behavioral therapy has been shown to be effective, at least when provided to willing patients by experienced therapists (31,32). “Explanatory therapy,” a similar but less technical approach originally described by Kellner (33), has also been shown to reduce hypochondriacal fears, emotional distress, and health care utilization, but it is not presently of proven benefit when administered by nonspecialists (34).

Pain Disorder

Description

Somatoform pain disorder is a chronic disorder characterized by unexplained or amplified complaints of pain (Table 21.8). It usually has its onset in the fourth or fifth decade and is associated with marked functional disability. The diagnosis is most useful when psychological factors can be linked to the onset and maintenance of pain. A typical scenario begins with lower back pain, which often develops on the job and is initially diagnosed as a sprain. The patient may see his or her primary care practitioner and attempt

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to return to work. Soon thereafter the pain recurs, sometimes after apparent reinjury. Specialty consultations (e.g., orthopedic, neurosurgical) ensue. Conservative treatments (e.g., physical therapy) are ineffective. Surgery may be performed, perhaps with transient benefit, but soon there is a resurgence of symptoms described as worse than ever. After 6 to 12 months of illness the patient is out of work, socially isolated, physically inactive, dependent on narcotic analgesics, angry, and demoralized. He or she may believe that health professionals and family members do not regard the pain as real.

TABLE 21.8 Diagnostic Criteria for Pain Disorder

1. Pain in one or more anatomic sites is the predominant focus of the clinical presentation and is of sufficient severity to warrant clinical attention.

2. The pain causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

3. Psychological factors are judged to have an important role in the onset, severity, exacerbation, or maintenance of the pain.

4. The symptoms are not intentionally produced or feigned (as in Factitional Disorder or Malingering).

5. The pain is not better accounted for by a mood, anxiety, or psychotic disorder and does not meet criteria for dyspareunia.

Reprinted with permission from Diagnostic and statistical manual of mental disorders. 4th Edition. Washington, DC: American Psychiatric Association, 1994.

Management

Treatment of somatoform pain disorder is similar to the management of other somatoform disorders:

  1. Review past medical recordsto determine the timing and extent of prior evaluations and treatments.
  2. Respond to pain complaints with a thorough history and physical examinationand determine that adequate medical, surgical, and neurologic evaluations have been done, but avoid procedures and hospitalization in the absence of clear indications.
  3. Review the four explanatory perspectives(see Why Patients Somatize) for factors that might be promoting unexplained or amplified pain complaints, and design a treatment plan that addresses specific etiologic factors identified: major psychiatric disease (especially major depression and chemical dependency, both of which are common in patients with somatoform pain), personality traits (especially exaggerated dependency), environmental reinforcers (e.g., financial compensation, relief from work responsibility, sympathy from family and friends), and aspects of life history that make the pain complaints empathically understandable (e.g., abusive or negligent parenting leading to a yearning to be cared for in a passive-dependent way that is often hidden behind a defiant facade).
  4. Convey optimism that improvement is likely, but do not promise cure or complete resolution of symptoms.
  5. Promote the performance of functions that are reasonable for the patient to perform despite symptoms, and praise patients for carrying out specific activities and being productive in the face of discomfort.
  6. Reassure the patient of your continuing availability, and schedule regular, brief visitsso that access to medical attention does not require exacerbation of symptoms.
  7. Consider topical treatments and physical therapybecause of their intrinsic value, safety, and symbolic value as indicators that the physical reality of the patient's pain is recognized.
  8. Generally, avoid prescribing benzodiazepines and narcotic analgesics, and persuade addicted patients to pursue detoxification. In selected patients who are functional on a stable opioid regimen, it is reasonable to maintain the regimen as part of a contractual plan for the management of chronic pain (see Chapter 29). Antidepressant medication may be of use in some patients, especially if the pain is neuropathic in nature (see Chapter 13) or if there is concomitant anxiety (see Chapter 22) or depression (see Chapter 24).
  9. Work with the patient to understand and accept the link between somatic symptoms and psychosocial stress(see above underAdjustment Disorder, Management).
  10. Attempt to direct the patient to discuss life problems, especially interpersonal conflicts and disappointments.
  11. Enlist the support of the patient's familyin an effort to reinforce maintenance of function in the face of symptoms rather than persistence of disability.
  12. Consider referral to a center specializing in the multidisciplinary careof patients with chronic pain syndromes.
  13. Try “mining for gold”(26) (see above under Somatization Disorder, Management).

Body Dysmorphic Disorder

Description

Body dysmorphic disorder is a disorder characterized by an excessive or completely unfounded preoccupation with a defect in personal appearance (Table 21.9). The prevalence of the disorder is unknown. Onset typically occurs between adolescence and age 30 years. Perceived facial imperfections, such as the shape of the nose or jaw, are the most common sources of concern.

TABLE 21.9 Diagnostic Criteria for Body Dysmorphic Disorder

1. Preoccupation with an imagined defect in appearance. If a slight physical anomaly is present, the person's concern is markedly excessive.

2. The preoccupation causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

3. The preoccupation is not better accounted for by another mental disorder (e.g., dissatisfaction with body shape and size in Anorexia Nervosa).

Reprinted with permission from Diagnostic and statistical manual of mental disorders. 4th Edition. Washington, DC: American Psychiatric Association, 1994.

Case Example

A 60-year-old man entered into psychiatric treatment for chronic depression. He reported long-standing attitudes and patterns of behavior suggesting obsessionality and extreme self-consciousness. He also reported a preoccupation beginning in adolescence with the shape of his jaw. He had undergone elaborate surgical treatment for this but continued to feel that other people were put off by his appearance, a belief contributing to his social discomfort. The examining psychiatrist found nothing remarkable about the appearance of his face. The patient's preoccupation with this perceived defect was partially ameliorated by antidepressant treatment, but he continued to regard himself as misshapen.

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Management

Little is known about the treatment and prognosis of the disorder. Some authors believe it should be regarded as a symptom, not as a distinct condition. Generally, patients should be discouraged from pursuing surgical solutions, especially when their concerns are entirely unfounded. Otherwise, many of the management guidelines described earlier for other chronic somatoform disorders are applicable. In particular, it is useful to review the four explanatory perspectives for factors promoting the development and maintenance of the symptoms and to treat any specific etiologic factor identified: an associated major psychiatric illness (usually major depression), personality types predisposing to the disorder (especially obsessive-compulsive and avoidant types—see Chapter 23), behavioral models for these concerns (e.g., parents who were dissatisfied with similar physical attributes in themselves), and aspects of the life story that make the symptoms empathically understandable (e.g., early experiences with critical parents leading the patient to feel unwanted or unacceptable).

Disorders with Voluntary Symptom Production

The fundamental feature of disorders with voluntary symptom production is the deliberate simulation of physical symptoms. This characteristic distinguishes patients with these disorders from those with chronic somatoform disorders, described earlier, in which symptom genesis is not deliberate.

TABLE 21.10 Diagnostic Criteria for Factitious Disorder with Physical Symptoms

1. Intentional production or feigning of physical or psychological signs or symptoms.

2. The motivation for the behavior is to assume the sick role.

3. External incentives for the behavior (such as economic gain, avoiding legal responsibility, or improving physical well-being, as in Malingering) are absent.

Reprinted with permission from Diagnostic and statistical manual of mental disorders. 4th Edition. Washington, DC: American Psychiatric Association, 1994.

Factitious Disorder with Physical Symptoms

Description

Factitious illness is characterized by the deliberate simulation of physical symptoms for the sole purpose of assuming the sick role (35). When this behavior is chronic and leads to multiple hospitalizations, it is known as chronic factitious disorder with physical symptoms (Table 21.10) or Munchhausen syndrome. When there is deliberate simulation of a psychiatric syndrome, it is designated as Factitious Disorder with Psychological Symptoms.

Patients may report invented symptoms (e.g., severe right lower quadrant abdominal pain), or they may deliberately produce physical signs by heating thermometers, tying tourniquets around their legs, or ingesting anticoagulant drugs. The history may be dramatic but vague in medically relevant detail. Onset is usually in early adulthood, often shortly after hospitalization for a bona fide physical illness. Job stability, family life, and other interpersonal relationships suffer profoundly as a result of multiple lengthy hospitalizations.

Management

The main goals of management are to prevent unnecessary hospitalizations and to avoid invasive procedures. The management of the hospitalized patient may be facilitated by early psychiatric consultation to assist in diagnosis, determine whether other treatable psychiatric disorders are present, help plan tactful confrontation of the patient with the diagnosis, and attempt to persuade the patient to accept psychiatric hospitalization.

Malingering

Description

Malingering is the deliberate simulation of physical (or psychological) symptoms to achieve a specific benefit. It

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is an important and common problem in settings where sickness is rewarded with certain benefits (e.g., avoidance of military service or court appearances, financial compensation for injuries). Malingering comprises three types (see Ford, athttp://www.hopkinsbayview.org/PAMreferences):

  1. Pure malingering, in which there is deliberate deception by the description or production of nonexistent symptoms or signs (rare)
  2. Partial malingering, which involves the conscious and voluntary exaggeration of symptoms of a real disease
  3. Deliberate attribution of an actual disability to an injury or accident that did not cause it

The diagnosis of malingering should be suspected whenever symptoms or disabilities greatly exceeding objective disease are accompanied by obvious social or financial benefit. Other observations suggesting the diagnosis include inconsistency of symptoms (e.g., a blind person detected reading), unusually vague or markedly exaggerated reports of symptoms, and the expression of indignant anger in response to gentle confrontation.

Malingering must be distinguished from factitious disorders, in which the patient has no goal aside from achieving patienthood, and from conversion disorders, in which symptom production is not conscious or intentional.

Management

The goal of management is to persuade malingering patients to give up their symptoms. Patients should gradually and tactfully be made aware that malingering is suspected, and the gratifications associated with the sick role should be removed. Reports of symptoms should be given minimal attention. If psychiatric disorders are thought to underlie or complicate apparent malingering, psychiatric consultation should be obtained.

Specific References*

For annotated General References and resources related to this chapter, visit http://www.hopkinsbayview.org/PAMreferences.

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