Atlas of Primary Care Procedures, 1st Edition

Gastroenterology

47

Anoscopy with Biopsy

Anorectal disorders result from a variety of causes, including infection, structural abnormalities, or systemic disorders. Anoscopy, a common procedure used to diagnose these conditions, is performed in ambulatory and emergency department settings. It is used to evaluate patients with rectal bleeding, those with perianal or anal complaints, sexual assault victims, and human immunodeficiency virus (HIV)-positive patients. It is also commonly performed in association with colonoscopy or flexible sigmoidoscopy.

The anorectum is the anatomic structure in which the endodermal intestine unites with the ectodermal anal canal and skin (see Figure 1). The dentate line (or pectinate line) marks the junction of these structures. The mucosa of the anal canal consists of stratified squamous epithelium without hair follicles or sweat glands. The most distal part of the anal canal (at the external opening) is the anal verge, where the epithelium thickens and hair follicles and cutaneous appendages appear. Proximal to the dentate line, the mucosa has 8 to 14 convoluted, longitudinal folds called the columns of Morgagni, with their associated crypts. At the base of some of these crypts is a small anal gland that secretes mucus to lubricate the anal canal. Two sleeves of circular muscles, the internal and external sphincters, surround the distal rectum and anal canal. Infection of these crypts and glands may result in cryptitis, fissures, abscesses, and fistulas (i.e., anal sepsis).

(1) The anatomy of the anal canal.

No bowel preparation is needed for an anoscopic examination. A digital examination should always precede an anoscopic examination to assess whether the patient will tolerate passage of an anoscope. The presence of an assistant is often helpful. A gloved assistant can separate the buttocks to allow better access and visibility of the perianal area. Inspection alone can reveal the presence of some fissures, fistulas, perianal dermatitis, masses, thrombosed external hemorrhoids, condyloma, and other growths.

Patients may perceive anoscopy as extremely embarrassing and uncomfortable. Objectively and honestly discuss the procedure with the patient while obtaining consent. Anoscopy generally has few complications; possibilities include minor lacerations, abrasions, or tearing of hemorrhoids. Bleeding occasionally occurs after biopsy, and infection is rare.

The Ives slotted anoscope provides the best unobstructed view of the walls of the anal canal. The slotted instrument does not compress the mucosa, so small

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lesions and hemorrhoids are more easily seen and treated. Because of its larger opening, it is the preferred instrument for treating hemorrhoids. The anoscope and obturator can be autoclaved. Disposable plastic anoscopes allow visualization of the compressed mucosa through the instrument, but they have a smaller working opening, and their use can result in failure to visualize small lesions.

INDICATIONS

  • Initial evaluation of rectal bleeding
  • Anal or perianal pain
  • Pruritus ani
  • Anal discharge
  • Rectal prolapse
  • External or internal hemorrhoids
  • Anal fissures or fistulas
  • Perianal condyloma
  • Palpable masses or excessive pain on digital examination
  • HIV-positive patients with high serum HIV load, a history of anal dysplasia, or condylomas

CONTRAINDICATIONS

  • Uncooperative patient
  • Severe debilitation
  • Acute myocardial infarction
  • Acute abdomen (relative contraindication)
  • Marked anal canal stenosis

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PROCEDURE

The anatomy of the anal canal is demonstrated.

Place the patient in the left lateral decubitus position with the left side down on the table and the head toward the left as the examiner faces the patient. Slightly flex the patient's hips and knees, and draw the buttocks slightly off the edge of the table toward the examiner.

(2) Place the patient in the left lateral decubitus position with the left side down on the table and the head toward the left as the examiner faces the patient.

PITFALL: Patients can be placed in a knee-chest position, but this is more uncomfortable for the patient to maintain.

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Visually inspect the external anus. Look for inflammation or other dermatologic conditions. Gently everting the buttocks usually everts the anus enough to visualize anal skin tags, perianal abscesses, thrombosed external hemorrhoids, and anal fissures. Look for a sentinel skin tag in the posterior or anterior midline that that would indicate the presence of a fissure.

(3) Visually inspect the external anus.

Start a digital anorectal examination by informing the patient that you will touch the anus. With a gloved finger well lubricated with a water-soluble lubricant or 2% lidocaine jelly, apply gentle pressure to the anal verge so that the examining finger enters the anal canal. Anal fissures manifest as palpable defects or indurations, usually in the posterior midline. Assess the prostate gland in male patients. Assess anal sphincter function by asking the patient to “squeeze down” as if to try to stop a bowel movement and by feeling for the tightening of the external sphincter. Sweep the examining finger around the entire distal rectum.

(4) Perform a digital anorectal examination.

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An Ives slotted anoscope is used with the obturator in place for insertion into the anal canal (Figure 5A) and withdrawn for viewing (Figure 5B).

(5) Ives slotted anoscope.

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With the obturator in place, lubricate the anoscope with a water-soluble lubricant or 2% lidocaine jelly. Ask the patient to gently take a few deep breaths. Insert the anoscope very gently into the anal aperture, gradually overcoming the resistance of the sphincters. Gently advance the instrument until the full length of the anoscope is inserted.

(6) With the obturator in place, lubricate the anoscope with a water-soluble lubricant, have the patient take a few deep breaths, and insert the anoscope very gently into the anal aperture.

Remove the obturator to examine the mucosa. Observe the appearance of the epithelium, the dentate line, the mucosal vasculature, and for any abnormal findings such as blood, mucus, pus, or hemorrhoids. Gradually withdraw the anoscope, observing the anal canal as it is extracted. Then rotate the anoscope 120 degrees, and repeat the process. Repeat the procedure until the entire circumference of the anal canal is examined. A variety of long-handled biopsy instruments can be used to take a biopsy specimen. Keep the biopsy superficial; only 3 or 4 mm of tissue are needed. Control any bleeding with pressure or Monsel's solution, or both.

(7) Remove the obturator to examine the mucosa.

PITFALL: If fecal matter is encountered, remove it with a large cotton swab.

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CODING INFORMATION

CPTŽ Code

Description

2002 Average 50th Percentile Fee

46600

Anoscopy

$65

46606

Anoscopy with biopsy, single or multiple

$128

46608

Anoscopy with foreign body removal

$219

CPTŽ is a trademark of the American Medical Association.

INSTRUMENT AND MATERIALS ORDERING

The Ives slotted anoscope ($160) is available from Redfield Corporation, 336 West Passaic Street, Rochelle Park, NJ (phone: 800-678-4472;http://www.redfieldcorp.com). A suggested anesthesia tray that can be used for this procedure is described in Appendix G.

BIBLIOGRAPHY

Daniel GL, Longo WE, Vernava AM 3rd. Pruritus ani: causes and concerns. Dis Colon Rectum 1994;37:670–674.

de Ruiter A, Carter P, Katz DR, et al. A comparison between cytology and histology to detect anal intraepithelial neoplasia. Genitourin Med 1994;70:22–25.

Ernst AA, Green E, Ferguson MT, et al. The utility of anoscopy and colposcopy in the evaluation of male sexual assault victims. Ann Emerg Med 2000;36:432–437.

Indinnimeo M, Cicchini C, Stazi A, et al. Analysis of a follow-up program for anal canal carcinoma. J Exp Clin Cancer Res 2001;20:199–203.

Kelly SM, Sanowski RA, Foutch PG, et al. A prospective comparison of anoscopy and fiber endoscopy in detecting anal lesions. J Clin Gastroenterol 1986;8:658–660.

Korkis AM, McDougall CJ. Rectal bleeding in patients less than 50 years of age. Dig Dis Sci 1995;40:1520–1523.

Lewis JD, Brown A, Localio AR, et al. Initial evaluation of rectal bleeding in young persons: a cost-effectiveness analysis. Ann Intern Med2002;136:99–110.

Sobhani I, Vuagnat A, Walker F, et al. Prevalence of high-grade dysplasia and cancer in the anal canal in human papillomavirus-infected individuals. Gastroenterology 2001;120:857–866.

Surawicz CM, Kirby P, Critchlow C, et al. Anal dysplasia in homosexual men: role of anoscopy and biopsy. Gastroenterology1993;105:658–666.

William DC, Felman YM, Riccardi NB. The utility of anoscopy in the rapid diagnosis of symptomatic anorectal gonorrhea in men. Sex Transm Dis 1981;8:16–17.



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