Vaccine
PREGNANCY RECOMMENDATION: Contraindicated
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
PREGNANCY SUMMARY
Mumps vaccine is a live attenuated virus vaccine (1,2). It should not be given in pregnancy. Animal reproduction studies have not been conducted with the vaccine.
FETAL RISK SUMMARY
Mumps occurring during pregnancy may result in an increased rate of 1st trimester spontaneous abortion (2). Although a fetal risk from the vaccine has not been confirmed, the vaccine should not be used during pregnancy because fetal infection with the attenuated viruses may occur (1–3). The manufacturer (2). In addition, the manufacturer recommends avoiding pregnancy for 3 months following vaccination (2). A shorter interval is recommended by the CDC (4), which recommends that women who receive the mumps vaccine should avoid becoming pregnant for 28 days. However, no cases of congenital malformations attributable to infection with mumps vaccine virus have been reported and having been vaccinated with the vaccine should not be a reason to terminate a pregnancy (5).
BREASTFEEDING SUMMARY
No reports describing the administration of mumps vaccine during human lactation have been located.
References
1.Amstey MS. Vaccination in pregnancy. Clin Obstet Gynaecol 1983;10:13–22.
2.Product information. Mumpsvax. Merck, 2001.
3.Linder N, Ohel G. In utero vaccination. Clin Perinatol 1994;21:663–74.
4.CDC. Guidelines for Vaccinating Pregnant Women. Available at http://www.cdc.gov/vaccines/pubs/preg-guide.htm. Accessed May 16, 2010.
5.CDC. Measles, mumps, and rubella-vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 1998;47(No. RR-8):1–57.