Vaccine
PREGNANCY RECOMMENDATION: Compatible—Maternal Benefit >> Embryo–Fetal Risk
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
PREGNANCY SUMMARY
Tularemia vaccine is a live, attenuated bacteria vaccine (1,2). Because tularemia is a severe disease, preexposure prophylaxis of indicated persons should occur regardless of pregnancy (1).
FETAL RISK SUMMARY
Tularemia is a serious infectious disease occurring primarily in laboratory personnel, rabbit handlers, and forest workers (1). The risk to the fetus from the vaccine is unknown. One report described vaccination in a woman early in the 1st trimester with transplacental passage of antibodies (2,3). No adverse effects were observed in the term infant or at 1-year follow-up.
BREASTFEEDING SUMMARY
No reports describing the administration of tularemia vaccine during human lactation have been located.
References
1.Amstey MS. Vaccination in pregnancy. Clin Obstet Gynaecol 1983;10:13–22.
2.Albrecht RC, Cefalo RC, O’Brien WF. Tularemia immunization in early pregnancy. Am J Obstet Gynecol 1980;138:1226–7.
3.Linder N, Ohel G. In utero vaccination. Clin Perinatol 1994;21:663–74.