Antibiotic (Cephalosporin)
PREGNANCY RECOMMENDATION: Compatible
BREASTFEEDING RECOMMENDATION: Compatible
PREGNANCY SUMMARY
No detectable teratogenic risk with cephalosporin antibiotics was found in a large 2001 study (see Cephalexin).
FETAL RISK SUMMARY
No reports describing the use of ceftibuten in human pregnancy have been located. It is an oral, semisynthetic cephalosporin antibiotic. Reproduction studies in rats found no evidence of impaired fertility at doses up to approximately 43 times the human dose based on BSA (HD). No teratogenesis or fetal harm was found in studies with rats and rabbits at doses up to approximately 8.6 and 1.5 times, respectively, the HD (1).
BREASTFEEDING SUMMARY
No reports describing the use of ceftibuten during human lactation have been located. Low concentrations of other cephalosporins are excreted into milk, however, and the presence of ceftibuten in milk should be expected. Three potential problems exist for the nursing infant exposed to ceftibuten in milk: modification of bowel flora, direct effects on the infant, and interference with the interpretation of culture results if a fever workup is required. The American Academy of Pediatrics classifies other cephalosporin antibiotics as compatible with breastfeeding (for example, see Cefadroxil and Cefazolin).
Reference
1.Product information. Cedax. Schering Corporation, 1997.