Diagnostic
PREGNANCY RECOMMENDATION: Limited Human Data—Probably Compatible
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
PREGNANCY SUMMARY
Iothalamate contains a high concentration organically bound iodine. See Diatrizoate for possible effects on the fetus and newborn.
FETAL RISK SUMMARY
Iothalamate has been used for diagnostic procedures during pregnancy. Amniography was performed in one patient to diagnose monoamniotic twinning shortly before an elective cesarean section (1). No effect on the two newborns was mentioned. In a second study, 17 women were given either iothalamate or metrizoate for ascending phlebography during various stages of pregnancy (2). Two patients, one exposed in the 1st trimester and the other in the 2nd trimester, were diagnosed as having deep vein thrombosis and were treated with heparin. The baby from the 2nd trimester patient was normal, but the other newborn had hyperbilirubinemia and undescended testis (2). The relationship between the diagnostic agents (or other drugs) and the defects is not known.
BREASTFEEDING SUMMARY
See DIATRIZOATE
References
1.Dunnihoo DR, Harris RE. The diagnosis of monoamniotic twinning by amniography. Am J Obstet Gynecol 1966;96:894–5.
2.Kierkegaard A. Incidence and diagnosis of deep vein thrombosis associated with pregnancy. Acta Obstet Gynecol Scand 1983;62:239–43.