Diuretic
PREGNANCY RECOMMENDATION: Limited Human Data—Probably Compatible
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
PREGNANCY SUMMARY
Isosorbide is an osmotic diuretic used for the short-term reduction of intraocular pressure in acute glaucoma before and after intraocular surgery. No published reports describing the use of isosorbide in pregnancy have been located.
FETAL RISK SUMMARY
In an FDA surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 13 newborns had been exposed to isosorbide during the 1st trimester (F. Rosa, personal communication, FDA, 1993). No major birth defects were observed (0.6 expected).
BREASTFEEDING SUMMARY
No reports describing the use of isosorbide during human lactation have been located.