Parasympatholytic (Anticholinergic)
PREGNANCY RECOMMENDATION: Limited Human Data—No Relevant Animal Data
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
PREGNANCY SUMMARY
The very limited pregnancy experience showing a possible association with minor malformations requires confirmation. In general, however, anticholinergics appear to be low risk in pregnancy (see Atropine).
FETAL RISK SUMMARY
Mepenzolate is an anticholinergic quaternary ammonium bromide. In a large prospective study, 2323 patients were exposed to this class of drugs during the 1st trimester, 1 of whom took mepenzolate (1). A possible association was found between the total group and minor malformations.
BREASTFEEDING SUMMARY
No reports describing the use of mepenzolate during human lactation have been located (see ATROPINE).
Reference
1.Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977:346–53.