Parasympatholytic (Anticholinergic)
PREGNANCY RECOMMENDATION: Limited Human Data—No Relevant Animal Data
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
PREGNANCY SUMMARY
The very limited pregnancy experience showing a possible association with minor malformations requires confirmation. In general, however, anticholinergics appear to be low risk in pregnancy (see Atropine).
FETAL RISK SUMMARY
Methscopolamine is an anticholinergic quaternary ammonium bromide derivative of scopolamine (see also Scopolamine). In a large prospective study, 2323 patients were exposed to this class of drugs during the 1st trimester, 2 of whom took methscopolamine (1). A possible association was found in the total group between this class of drugs and minor malformations.
BREASTFEEDING SUMMARY
No reports describing the use of methscopolamine during human lactation have been located (see also Atropine).
Reference
1.Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977:346–53.