Antibiotic (Penicillin)
PREGNANCY RECOMMENDATION: Compatible
BREASTFEEDING RECOMMENDATION: Compatible
PREGNANCY SUMMARY
Although the reported pregnancy experience with nafcillin is limited, all penicillins are considered low risk in pregnancy.
FETAL RISK SUMMARY
Nafcillin is a penicillin antibiotic (see also Penicillin G). No reports linking its use with congenital defects have been located. The Collaborative Perinatal Project monitored 50,282 mother–child pairs, 3546 of whom had 1st trimester exposure to penicillin derivatives (1, pp. 297–313). For use anytime during pregnancy, 7171 exposures were recorded (1, p. 435). In neither group was evidence found to suggest a relationship to large categories of major or minor malformations or to individual defects.
BREASTFEEDING SUMMARY
No reports describing the use of nafcillin during human lactation have been located. (See also Penicillin G.)
Reference
1.Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977.