Antibiotic (Penicillin)
PREGNANCY RECOMMENDATION: Compatible
BREASTFEEDING RECOMMENDATION: Compatible
PREGNANCY SUMMARY
Procaine penicillin G is an equimolar combination of procaine and penicillin G suspended in water (1). The combination is broken down in vivo into the two components. Reproduction studies in mice, rats, and rabbits have revealed no evidence of impaired fertility or fetal harm (2) (see also Penicillin G). The antibiotic is considered low risk in pregnancy.
FETAL RISK SUMMARY
A case report described the use of high doses of penicillin G procaine IV,* cortisone, and sodium salicylate in early pregnancy followed by the delivery at term of a cyclopic male infant (3). The lethal defect was attributed to salicylates, cortisone, or maternal viremia. (*Penicillin G procaine should not be given IV. Presumably, the drug was either given IM or the procaine form was not used. Attempts to clarify this with the authors have been unsuccessful.)”
BREASTFEEDING SUMMARY
See PENICILLIN G
References
1.Mandel G, Sande M. Antimicrobial agents (continued). Penicillins and cephalosporins. In Gilman AG, Goodman LS, Gilman A, eds. The Pharmacological Basis of Therapeutics. 6th ed. New York, NY: MacMillan, 1980:1137.
2.Product information. Bicillin C-R. Wyeth-Ayerst Pharmaceuticals, 2000.
3.Khudr G, Olding L. Cyclopia. Am J Dis Child 1973;125:120–2.