Parasympatholytic (Anticholinergic)
PREGNANCY RECOMMENDATION: Limited Human Data—No Relevant Animal Data
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
PREGNANCY SUMMARY
Propantheline is an anticholinergic quaternary ammonium bromide. There are no reports associating the use of this drug with developmental toxicity, but the data are limited. There also are no relevant animal data. (See also Atropine.)
FETAL RISK SUMMARY
The Collaborative Perinatal Project monitored 50,282 mother–child pairs, 33 of whom used propantheline in the 1st trimester (1). No evidence was found for an association with congenital malformations. When the group of parasympatholytics were taken as a whole (2323 exposures), a possible association with minor malformations was found (1).
BREASTFEEDING SUMMARY
No reports describing the use of propantheline during human lactation have been located. (See also Atropine.)
Reference
1.Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977:346–53.