QUINAPRIL (ACCUPRIL, GENERIC)
WARNING: ACE inhibitor used during pregnancy can cause fet al injury & death.
USES: *HTN, CHF, DN, post-MI.*
ACTIONS: ACE inhibitor.
DOSE: 10–80 mg PO daily; ↓ in renal impairment.
W/P: [D, +] w/ RAS, vol depletion.
CI: ACE inhibitor sensitivity, angioedema, pregnancy.
DISP: Tabs 5, 10, 20, 40 mg.
SE: Dizziness, headache, ↓ BP, impaired renal function, angioedema, taste perversion, cough.
QUINUPRISTIN/DALFOPRISTIN (SYNERCID)
USES: *Vancomycin-resistant infections d/t E. faecium & other gram(+).*
ACTIONS: ↓ Ribosomal protein synth. Spectrum: Vancomycin-resistant E. faecium, methicillin-susceptible S. aureus, S. pyogenes; not against E. faecalis.
DOSE:
Adults & Peds: 7.5 mg/kg IV q12h (central line preferred); incompatible w/ NS or heparin; flush IV w/ dextrose; ↓ w/ hepatic failure.
W/P: [B, M] Multiple drug interactions w/ drugs metabolized by CYP3A4 (eg, cyclosporine).